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- Title
PAN-orama: three convergent views of a eukaryotic deadenylase.
- Authors
Martin, Sophie; Coller, Jeff
- Abstract
The article explores the three new studies that emphasize the biochemical and structural features of PAN2-PAN3 complex, the key enzymes in eliminating poly(A) tails. It states that the shortening or lengthening of the 3 poly(A) tails of a transcript can contribute on the post-transcriptional regulation of mRNA. It adds that as the results of the studies offer limited picture of deadenylation, a more detailed biochemical studies have been anticipated to come.
- Subjects
PROTEIN genetics; ENZYMES; RIBONUCLEASES; MESSENGER RNA; DEADENYLATION; GENE expression; NUCLEOTIDES; ADENOSINE monophosphate
- Publication
Nature Structural & Molecular Biology, 2014, Vol 21, Issue 7, p577
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2850