We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.
- Authors
Knowles, Timothy J.; Scott-Tucker, Anthony; Overduin, Michael; Henderson, Ian R.
- Abstract
The folding of transmembrane proteins into the outer membrane presents formidable challenges to Gram-negative bacteria. These proteins must migrate from the cytoplasm, through the inner membrane and into the periplasm, before being recognized by the β-barrel assembly machinery, which mediates efficient insertion of folded β-barrels into the outer membrane. Recent discoveries of component structures and accessory interactions of this complex are yielding insights into how cells fold membrane proteins. Here, we discuss how these structures illuminate the mechanisms responsible for the biogenesis of outer membrane proteins.
- Subjects
MEMBRANE proteins; GRAM-negative bacteria; CYTOPLASM; PROTEIN folding; CELL membrane formation; CYTOLOGY
- Publication
Nature Reviews Microbiology, 2009, Vol 7, Issue 3, p206
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2069