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- Title
Effects of Nocturnal Branched-Chain Amino Acid on Protein Metabolism in Patients with Liver Cirrhosis.
- Authors
Fukushima, Hideki; Miwa, Yoshiyuki; Tomita, Eiichi; Ida, Erika; Kuriyama, Naoko; Toda, Katsuhiko; Shimomura, Yoriko; Sugiyama, Akihiko; Sugihara, Jun'ichi; Moriwaki, Hisataka
- Abstract
Aim: We have reported previously that oral administration of branched-chain amino acids (BCAA) is effective to improve serum albumin and patients' prognosis. We herein studied the effects of nocturnal BCAA on protein metabolism in patients with liver cirrhosis. Methods: Twelve patients with liver cirrhosis participated in this study. All subjects ate isonitrogenous and isocaloric diets for a week prior to the study. On day 8, indirect calorimetry was carried out, and BCAA, Fischer's ratio and nitrogen balance were also examined. Patients were then administered either with regular BCAA (4g BCAA after each meal, n=6) or with nocturnal BCAA (4g after breakfast and 8g before bedtime, n=6) for one week. On day 14, the same examination was carried out. The cross-over study was performed for the third week in the same patients. Six patients were followed up with nocturnal BCAA supplementation for one month. Results: After ordinary administration of BCAA, Fischer's ratio and nitrogen balance were improved. These two parameters were further improved after nocturnal BCAA. One-month nocturnal BCAA improved serum albumin in the patients. Conclusions: Nocturnal BCAA could improve serum albumin in liver cirrhosis who did not respond to ordinary BCAA. This effect could be partly due to increased Fischer's ratio and its protein-sparing effect during the night time.
- Subjects
BRANCHED chain amino acids; SERUM albumin; CIRRHOSIS of the liver; PROGNOSIS; PROTEIN metabolism
- Publication
Asia Pacific Journal of Clinical Nutrition, 2002, Vol 11, pS53
- ISSN
0964-7058
- Publication type
Article