We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Patient-specific finite element modeling of the Cardiokinetix Parachute device: effects on left ventricular wall stress and function.
- Authors
Lee, Lik; Ge, Liang; Zhang, Zhihong; Pease, Matthew; Nikolic, Serjan; Mishra, Rakesh; Ratcliffe, Mark; Guccione, Julius
- Abstract
The Parachute (Cardiokinetix, Inc., Menlo Park, California) is a catheter-based device intended to reverse left ventricular (LV) remodeling after antero-apical myocardial infarction. When deployed, the device partitions the LV into upper and lower chambers. To simulate its mechanical effects, we created a finite element LV model based on computed tomography (CT) images from a patient before and 6 months after Parachute implantation. Acute mechanical effects were determined by in silico device implantation (VIRTUAL-Parachute). Chronic effects of the device were determined by adjusting the diastolic and systolic material parameters to better match the 6-month post-implantation CT data and LV pressure data at end-diastole (ED) (POST-OP). Regional myofiber stress and pump function were calculated in each case. The principal finding is that VIRTUAL-Parachute was associated with a 61.2 % reduction in the lower chamber myofiber stress at ED. The POST-OP model was associated with a decrease in LV diastolic stiffness and a larger reduction in myofiber stress at the upper (27.1 %) and lower chamber (78.4 %) at ED. Myofiber stress at end-systole and stroke volume was little changed in the POST-OP case. These results suggest that the primary mechanism of Parachute is a reduction in ED myofiber stress, which may reverse eccentric post-infarct LV hypertrophy.
- Subjects
SURGICAL equipment; LEFT heart ventricle surgery; FINITE element method; HEART function tests; CARDIAC catheterization; VENTRICULAR remodeling
- Publication
Medical & Biological Engineering & Computing, 2014, Vol 52, Issue 6, p557
- ISSN
0140-0118
- Publication type
Article
- DOI
10.1007/s11517-014-1159-5