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- Title
New validated HPLC methodology for the determination of (−)- trans-paroxetine and its enantiomer in pharmaceutical formulations with use of ovomucoid chiral stationary phase.
- Authors
Lisowska-Kuźmicz, Małgorzata; Kantor-Boruta, Małgorzata; Jończyk, Anna; Jarończyk, Małgorzata; Ocios-Bębenek, Agnieszka; Mazurek, Aleksander; Chilmonczyk, Zdzisław; Jarosz, Maciej
- Abstract
A new chromatographic method for the enantioseparation and the determination of (−)- trans-paroxetine and (+)- trans-paroxetine has been developed with the aid of amylose ovomucoid-based chiral stationary phase. The method is faster and five times more sensitive than procedures recommended previously: limit of detection and limit of quantification are 5 and 16 ng/mL, respectively [modified (Ferretti et al. in J Chromatogr B 710:157-164, ): 20 and 60 ng/mL]. It was carefully validated and applied for the determination of (−)- trans-paroxetine and (+)- trans-paroxetine in Parogen (Mc Dermott Laboratories Ltd.) and Xetanor (Actavis) coated tablets. [Figure not available: see fulltext.]
- Subjects
SEPARATION of enantiomers; DRUG efficacy; HIGH performance liquid chromatography; PAROXETINE; OVOMUCOID; CHIRAL stationary phases
- Publication
Analytical & Bioanalytical Chemistry, 2014, Vol 406, Issue 15, p3697
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-013-7565-y