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- Title
Evidence of long-lasting anti-CD19 activity of engrafted CD19 chimeric antigen receptor-modified T cells in a phase I study targeting pediatrics with acute lymphoblastic leukemia.
- Authors
Ma, Futian; Ho, Jin‐Yuan; Du, Huan; Xuan, Fan; Wu, Xiaoli; Wang, Qinglong; Wang, Lin; Liu, Ying; Ba, Min; Wang, Yizhuo; Luo, Jianmin; Li, Jianqiang; Ho, Jin-Yuan
- Abstract
Ninety percent of relapse/refractory B-cell acute lymphatic leukemia (R/R B-ALL) patients can achieve complete remission (CR) after CD19-targeting chimeric antigen receptor T (CAR-T) cell therapy. However, around 50% of them relapse in 1 year. Persistent CAR-T cell engraftment is considered as the key to remain durable remission. Here, we initiated a phase I study to treat 10 pediatric B-ALL patients using a CD19-targeted second generation CAR with a 4-1BB intracellular costimulatory domain. All patients received a standard fludarabine and cyclophosphamide (FC) preconditioning regiment, followed by a CAR-T infusion with a median number of 0.5 (0.3-1.58) × 106 CAR+ T cells/kg. The pretreatment tumor burdens were high with a median bone marrow (BM) blasts percentage of 59.2% (7.31%-86.2%), excluding one patient only with brain infiltration of leukemia cells (0% BM blasts). The initial CR rate was 80% (n = 8/10). Four patients (40%) experienced serious (grade > 2) cytokine release syndrome (CRS) and three patients (30%) with obvious neurotoxicity. Monthly assessments of CD19+ minimal residual disease (MRD) and CAR-T engraftment demonstrated the anti-CD19 activity of long-term engrafted CAR-T cell clones in one patient for more than 2 years.
- Subjects
CD19 antigen; LYMPHOBLASTIC leukemia; ACUTE leukemia; T cells; CHIMERIC antigen receptors; CELLULAR therapy
- Publication
Hematological Oncology, 2019, Vol 37, Issue 5, p601
- ISSN
0278-0232
- Publication type
journal article
- DOI
10.1002/hon.2672