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- Title
Predictors of thrombosis in testicular cancer during platinum-based chemotherapy.
- Authors
Paffenholz, Pia; Grein, Katharina; Heidegger, Isabel; Nestler, Tim; Grabbert, Markus; Salem, Johannes; Hellmich, Martin; Pfister, David; Heidenreich, Axel
- Abstract
Purpose: To identify potential risk factors for the development of venous thromboembolic events in testicular cancer patients receiving platinum-based chemotherapy. Methods: We performed a retrospective analysis including 255 patients with testicular germ cell tumors who received platinum-based chemotherapy from 2003 to 2018 as a multi-center observational cohort study. Patient and tumor characteristics of patients with and without a thromboembolic event were analyzed. Results: 49 (19%) patients experienced a venous thromboembolic event, with the majority representing pulmonary embolism and deep venous thrombosis (47%). There were no significant differences regarding the development of a venous thromboembolic event between first- and second-line regimes. Multivariate analysis showed an increased risk for a venous thromboembolic event in patients with clinical stage ≥ IIC disease (OR 2.259 [95% CI 1.105–4.618], p = 0.026), elevated serum LDH (OR 2.162 [95% CI 1.018–4.593], p = 0.045), febrile neutropenia (OR 2.973 [95% CI 1.363–6.487], p = 0.006) and central venous access (OR 3.465 [95% CI 1.068–11.243], p = 0.039). Patients suffering from a venous thromboembolic event revealed a significantly reduced overall survival (p = 0.033) during a median follow-up of 8 months [IQR 2–18]. Conclusions: 19% of all patients treated by platinum-based chemotherapy due to testicular cancer suffered from a venous thromboembolic event, associated with reduced overall survival. As a result, monitoring of cancer patients at risk as well as the improvement of patients' awareness of a thromboembolic event should thus be the main goal of their treating physicians.
- Subjects
TESTICULAR cancer; GERM cell tumors; VENOUS thrombosis; TERATOCARCINOMA; THROMBOSIS; FEBRILE neutropenia; CANCER chemotherapy
- Publication
World Journal of Urology, 2019, Vol 37, Issue 9, p1907
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-018-2598-7