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- Title
Structural Insights in Mammalian Sialyltransferases and Fucosyltransferases: We Have Come a Long Way, but It Is Still a Long Way Down.
- Authors
Grewal, Ravneet Kaur; Shaikh, Abdul Rajjak; Gorle, Suresh; Kaur, Manjeet; Videira, Paula Alexendra; Cavallo, Luigi; Chawla, Mohit
- Abstract
Mammalian cell surfaces are modified with complex arrays of glycans that play major roles in health and disease. Abnormal glycosylation is a hallmark of cancer; terminal sialic acid and fucose in particular have high levels in tumor cells, with positive implications for malignancy. Increased sialylation and fucosylation are due to the upregulation of a set of sialyltransferases (STs) and fucosyltransferases (FUTs), which are potential drug targets in cancer. In the past, several advances in glycostructural biology have been made with the determination of crystal structures of several important STs and FUTs in mammals. Additionally, how the independent evolution of STs and FUTs occurred with a limited set of global folds and the diverse modular ability of catalytic domains toward substrates has been elucidated. This review highlights advances in the understanding of the structural architecture, substrate binding interactions, and catalysis of STs and FUTs in mammals. While this general understanding is emerging, use of this information to design inhibitors of STs and FUTs will be helpful in providing further insights into their role in the manifestation of cancer and developing targeted therapeutics in cancer.
- Subjects
SIALYLTRANSFERASES; FUCOSYLTRANSFERASES; DRUG target; CELL membranes; CATALYTIC domains; GLYCOCALYX; GLYCANS
- Publication
Molecules, 2021, Vol 26, Issue 17, p5203
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26175203