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- Title
High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death.
- Authors
Dong Ho Kang; Rok Won Heo; Chin-ok Yi; Hwajin Kim; Chang Hwa Choi; Gu Seob Roh; Kang, Dong Ho; Heo, Rok Won; Yi, Chin-Ok; Kim, Hwajin; Choi, Chang Hwa; Roh, Gu Seob
- Abstract
<bold>Background: </bold>Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on neuroinflammation and oxidative stress in the hippocampus of kainic acid (KA)-treated mice.<bold>Results: </bold>Mice were fed with a HFD or normal diet for 8 weeks and then received a systemic injection of KA. HFD-fed mice showed hypercholesterolemia, insulin resistance, and hepatic steatosis. HFD-fed mice showed greater susceptibility to KA-induced seizures, an increased number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells, neuroinflammation, and oxidative stress. Furthermore, we found that KA treatment increased HFD-induced calpain1, nuclear factor E2-related factor 2, and heme oxygenase-1 expression in the hippocampus.<bold>Conclusions: </bold>These findings imply that complex mechanisms affected by obesity-induced systemic inflammation, neuroinflammation, ER stress, calcium overload, and oxidative stress may contribute to neuronal death after brain injury.
- Subjects
OBESITY complications; ANIMAL experimentation; ANIMALS; CELL death; SEIZURES (Medicine); DIET; FATTY liver; GENETIC techniques; HETEROCYCLIC compounds; HIPPOCAMPUS (Brain); HYPERCHOLESTEREMIA; INFLAMMATION; INSULIN resistance; MICE; NEURONS; SPASMS; OXIDATIVE stress; EXCITATORY amino acid agonists
- Publication
BMC Neuroscience, 2015, Vol 16, p1
- ISSN
1471-2202
- Publication type
journal article
- DOI
10.1186/s12868-015-0202-2