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- Title
Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves.
- Authors
Khlifi, Daycem; Hamdi, Moktar; El Hayouni, Akrem; Cazaux, Sylvie; Souchard, Jean Pierre; Couderc, François; Bouajila, Jalloul
- Abstract
In this work, an evaluation of the biological activities of Globularia alypum L. extracts and their global chemical composition was realized. Extracts from G. alypum were obtained by two extraction methods. The composition of polyphenols (8.5-139.95 g gallic acid equivalent/Kg of dry mass), tannins (1.39-18.65 g catechin equivalent/Kg of dry mass), anthocyanins (8.17-70.69 mg cyanidin equivalent/Kg of dry mass) and flavonoids (0.31-19.28 g quercetin equivalent/Kg of dry mass) was evaluated. The samples were subjected to a screening for their antioxidant activities using the DPPH• and ABTS•+ assays. For the first time, the anti-tuberculosis activity (H37Rv) for G. alypum was tested against Mycobacterium tuberculosis. The strongest antioxidant activity was obtained for the methanol extract (IC50 = 15.58 ± 0.168 mg/L) and the best anti-tuberculosis activity was obtained for the petroleum ether extract (IC50 = 77 mg/L). We have found a positive correlation between the total phenolics content and the antioxidant activity R² = 0.88 (DPPH•) and R² = 0.97 (ABTS•+). We have found also a positive correlation between the flavonoid content and the antioxidant activity R² = 0.91 (DPPH•) and R² = 0.91 (ABTS•+).
- Subjects
THERAPEUTIC use of plant extracts; ANTIOXIDANTS; COUGH treatment; CHEMICAL reactions; CHEMICAL structure; GLOBULARIACEAE
- Publication
Molecules, 2011, Vol 16, Issue 12, p10592
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules161210592