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- Title
Alkylation of 2,4-(1H,3H)-Quinazolinediones with Dialkyl Carbonates Under Microwave Irradiations.
- Authors
Rivero, Ignacio Alfredo; Guerrero, Leticia; Espinoza, Karla Alejandra; Meza, Martha Cecilia; Rodríguez, Jesús Ramón
- Abstract
Alkylation is a very important chemical reaction which modifies the biological properties of drugs. Quinazolinedione derivatives are of considerable interest due to their wide array of pharmacological properties. We now report application of a practical alkylation procedure to several quinazolinediones, including pelanserine (5f), which shows antihypertensive properties, 1-methyl-3-(2′-phenylethyl)-1H,3H-quinazoline-2,4-dione (1ab) and 1-methyl-3-[2′-(4′-methoxyphenyl)ethyl]-lH,3H-quinazoline-2,4-dione (1ae), which had been isolated from natural sources. The alkylation was optimized using dimethyl and diethyl carbonates under microwave irradiations.
- Subjects
ALKYLATION; CHEMICAL reactions; HYDROCARBONS; QUINAZOLINE; HETEROCYCLIC compounds; AROMATIC compounds; MICROWAVES; PHARMACOLOGY; ABDERHALDEN reaction
- Publication
Molecules, 2009, Vol 14, Issue 5, p1860
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14051860