We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Moderate effects of apple juice consumption on obesity-related markers in obese men: impact of diet-gene interaction on body fat content.
- Authors
Barth, Stephan; Koch, Tatiana; Watzl, Bernhard; Dietrich, Helmut; Will, Frank; Bub, Achim
- Abstract
Purpose: The effect of polyphenol-rich cloudy apple juice (CloA) consumption on plasma parameters related to the obesity phenotype and potential effects of interactions between CloA and allelic variants in obesity candidate genes were assessed in obese men. Methods: In this controlled, randomized, and parallel study, n = 68, non-smoking, non-diabetic men with a BMI ≥27 kg/m received 750 mL/day CloA (802.5 mg polyphenols) or 750 mL/day control beverage (CB, isocaloric equivalent to CloA) for 4 weeks. Further, study participants were genotyped for single-nucleotide polymorphisms in PPARγ (rs1801282), UCP3 (rs1800849), IL-6 (rs1800795), FABP2 (rs1799883), INSIG2 (rs7566605), and PGC1 (rs8192678) genes. At the beginning and at the end of intervention plasma lipids, distinct adipokines and cytokines as well as anthropometric parameters were determined. Results: CloA compared to CB had no significant effect on plasma lipids, plasma adipokine and cytokine levels, BMI, and waist circumference. However, CloA consumption significantly reduced percent body fat compared to CB (∆ % body fat: CloA: −1.0 ± 1.3 vs. CB: −0.2 ± 0.9, p < 0.05). The IL-6-174 G/C polymorphism showed an interaction with body fat reduction induced by CloA. Solely in C/C, but not in G/C or G/G variants, a significant reduction in body fat after 4 weeks of CloA intervention was detectable. Conclusion: The observed diet-gene interaction might be a first indication for the impact of individual genetic background on CloA-mediated bioactivity on obesity-associated comorbidities.
- Subjects
GERMANY; BODY composition; ALLELES; ANALYSIS of variance; APPLES; BIOMARKERS; CLINICAL trials; CYTOKINES; FRUIT juices; GENES; GENETIC polymorphisms; GLUCOSE tolerance tests; BIOELECTRIC impedance; MEN'S health; NONPARAMETRIC statistics; NUTRITION; OBESITY; PEPTIDE hormones; POLYPHENOLS; RESEARCH funding; STATISTICAL sampling; STATISTICS; T-test (Statistics); PHENOTYPES; GENOMICS; DATA analysis; BODY mass index; BLIND experiment; DATA analysis software; DESCRIPTIVE statistics
- Publication
European Journal of Nutrition, 2012, Vol 51, Issue 7, p841
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-011-0264-6