We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fever within 2 Weeks of Sorafenib Therapy Predicts Favorable Treatment Efficacy in Patients with Advanced Hepatocellular Carcinoma.
- Authors
Kuzuya, Teiji; Ishigami, Masatoshi; Ishizu, Yoji; Honda, Takashi; Hayashi, Kazuhiko; Ishikawa, Tetsuya; Nakano, Isao; Goto, Hidemi; Hirooka, Yoshiki
- Abstract
Objectives: The aim of this study was to investigate the relationship between fever within 2 weeks after the start of sorafenib therapy and treatment efficacy in patients with advanced hepatocellular carcinoma (HCC).Methods:One hundred and two patients with advanced HCC were enrolled in this study. We retrospectively compared patients with fever (more than 38°C) within 2 weeks after the start of sorafenib therapy (fever group, n = 34) and patients without fever (non-fever group, n = 68) in terms of survival, best antitumor response, and change in intratumor blood on contrast-enhanced computed tomography (CE-CT) after 2 weeks of sorafenib therapy. Results: Fever was the only significant and independent predictor of better outcomes (hazard ratio, 0.517; 95% confidence interval, 0.319-0.838; p = 0.0071). In thefever group, the partial response rate, the disease control rate, and the rate of disappearance of arterial tumor enhancement on CE-CT after 2 weeks of sorafenib therapy were significantly higher than those in the non-fever group (38.2 vs. 5.9%, respectively, p = 0.0001; 85.3 vs. 60.3%, respectively, p = 0.0103; 76.5 vs. 35.3%, respectively, p < 0.0001). Conclusions: Fever within 2 weeks after the start of sorafenib therapy may be a useful predictor of a favorable treatment response in patients with advanced HCC.
- Subjects
CONFIDENCE intervals; FEVER; HEPATOCELLULAR carcinoma; PROBABILITY theory; TREATMENT effectiveness; RETROSPECTIVE studies; DESCRIPTIVE statistics; SORAFENIB; PHARMACODYNAMICS; PROGNOSIS
- Publication
Oncology, 2016, Vol 91, Issue 5, p261
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000449000