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- Title
Effects of Doxorubicin and/or Cilostazol on Cancer Cells during Liver Regeneration after Two-Thirds Hepatectomy in Rats.
- Authors
Ikeda, Yasuharu; Matsumata, Takashi; Takenaka, Kenji; Yamagata, Motoyuki; Sugimachi, Keizo
- Abstract
A rat model of liver metastases generated by intraportal injection of syngeneic tumor cells after two-thirds hepatectomy to determine the optimal benefit of doxorubicin and/or cilostazol for early hepatic metastases. Four groups of WKA rats had viable tumor cells injected directly into the portal vein after two-thirds hepatectomy. Group A underwent to further treatment. Group B had doxorubicin injected 24 h post-operatively. Group C had cilostazol administered prior to two-thirds hepatectomy. Group D received cilostazol, and doxorubicin injections. The mean survival period in each group was 22.2, 20.0, 28.8, and 22.8 days, respectively. The mean survival was significantly longer in group C than in groups A, B and D (p < 0.05). Based on these findings, we believe that during the phase of liver regeneration adjuvant chemotherapy is not recommended. Cilostazol exerts an important antiproliferative effect on liver metastases after hepatectomy.
- Subjects
DOXORUBICIN; ANTHRACYCLINES; CANCER cells; CELLULAR pathology; HEPATECTOMY; LIVER surgery
- Publication
Oncology, 1998, Vol 55, Issue 4, p354
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000011877