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- Title
Immunohistochemical Detection of Estrogen Receptor in Invasive Human Breast Cancer: Correlation with Heat Shock Proteins, pS2 and Oncogene Products.
- Authors
Takahashi, Shuji; Narimatsu, Eimei; Asanuma, Hiroko; Okazaki, Minoru; Okazaki, Akira; Hirata, Koichi; Mori, Michio; Chiba, Takayuki; Sato, Noriyuki; Kikuchi, Kokichi
- Abstract
The authors immunohistochemically studied the expression of the estrogen receptor (ER), 27-kD heat shock protein (HSP27) and pS2 in 118 invasive primary human breast cancers. Positive nuclear staining of the ER was detected in 64% of the cases and was closely correlated wtih the biochemical assay (p < 0.0001). ER-positive tumors were significantly decreased with tumor size and stage (p < 0.001 each), but not with lymph node status. Positiv-ity of the ER was correlated with the cytoplasmic expression of HSP27 (p < 0.005), pS2 (not significant) and HSP70 (not significant). ER negativity was significantly correlated with the expression of p53, epidermal growth factor receptor (EGFR) and c-erbB-2 (p < 0.05 each). Thus, it was concluded that ER-positive breast carcinomas, relatively small in size, preferentially expressed HSP27, HSP70 and pS2 and that ER-negative tumors, relatively large in size, were predisposed to express p53, EGFR and c-erbB-2. Copyright © 1995 S. Karger AG, Basel
- Publication
Oncology, 1995, Vol 52, Issue 5, p371
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227491