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- Title
Expression of p53 and Glutathione S-Transferase-π Relates to Clinical Drug Resistance in Non-Small Cell Lung Cancer.
- Authors
Nakanishi, Yoichi; Kawasaki, Masayuki; Bai, Fen; Takayama, Koichi; Pei, Xin-Hai; Takano, Koichi; Inoue, Koji; Osaki, Sin-ichi; Hara, Nobuyuki; Kiyohara, Chikako
- Abstract
To determine the predictive value of the expression of p53 and glutathione S-transferase-π (GST-π) with respect to chemotherapy response, immunostaining was performed on transbronchial biopsy specimens from previously untreated patients with non-small cell lung cancer. Of the 54 patients, 34 patients (63%) and 37 patients (69%) were positive for p53 and GST-π, respectively. The response rates in the p53-positive and p53-negative group were 15 and 45%, and those in GST-π-positive and GST-π-negative groups were 16 and 47%, respectively. A multiple logistic regression analysis revealed that positive immunostaining for GST-π was a significant risk factor for clinical chemotherapy resistance. The combination of these two markers was the most important independent factor in predicting a response to chemotherapy in multiple logistic regression analysis. Immunohistochemical expression of p53 and GST-π was independently related to clinical chemoresistance in patients with non-small cell lung cancer. Combined use of these two biomarkers may be a useful predictor of clinical chemoresistance.Copyright © 1999 S. Karger AG, Basel
- Subjects
DRUG therapy; THERAPEUTICS; CISPLATIN; GLUTATHIONE transferase; LUNG cancer; P53 antioncogene; BIOPSY
- Publication
Oncology, 1999, Vol 57, Issue 4, p318
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000012068