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- Title
Antigenic specificity of antibodies from patients with linear basement membrane deposition of IgA.
- Authors
Zone, J J; Pazderka Smith, E; Powell, D; Taylor, T B; Smith, J B; Meyer, L J
- Abstract
We reviewed the immunoreactivity of sera binding to the epidermal side of basement membrane split skin from 13 adults and 8 children with IgA alone, 9 adults with IgA and IgG and 7 adults with IgA and ocular pemphigoid. Immunoblots were done against previously described 45-, 97-, 180- and 230-kD antigens, and reactivity was confirmed by elution of antibody from nitrocellulose and binding to the basement membrane. Ten of 13 adults and 7 of 8 children reacted with the 97-kD antigen. Sera with both IgA and IgG reacted in varying patterns and on occasion with more than 1 antigen. All 7 patients with ocular cicatricial pemphigoid reacted uniquely with a 45-kD antigen.
- Publication
Dermatology (10188665), 1994, Vol 189, Issue 1, p64
- ISSN
1018-8665
- Publication type
journal article