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- Title
Hallmarks of pluripotency.
- Authors
De Los Angeles, Alejandro; Ferrari, Francesco; Xi, Ruibin; Fujiwara, Yuko; Benvenisty, Nissim; Deng, Hongkui; Hochedlinger, Konrad; Jaenisch, Rudolf; Lee, Soohyun; Leitch, Harry G.; Lensch, M. William; Lujan, Ernesto; Pei, Duanqing; Rossant, Janet; Wernig, Marius; Park, Peter J.; Daley, George Q.
- Abstract
Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.
- Subjects
PLURIPOTENT stem cells; STEM cell research; CELL differentiation; TOTIPOTENCY (Cytology); GENOMICS
- Publication
Nature, 2015, Vol 525, Issue 7570, p469
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature15515