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- Title
The evaluation of various methods and antigens for the detection of antibodies against <em>Pityrosporum ovale</em> in patients with seborrhoeic dermatitis.
- Authors
Bergbrant, I.-M.; Johansson, S.; Robbins, D.; Bengtsson, K.; Faergemann, J.; Scheynius, A.; Soderstrom, T.
- Abstract
Sera from 10 patients with seborrhoeic dermatitis and from 10 age-matched healthy individuals were examined for IgG activity against <em>Pityrosporum ovale</em>. The IgG activity was analysed using the following techniques: an enzyme-linked immunosorbent assay (ELISA) against whole <em>P. ovale</em> cells, purified cell-wall carbohydrate or protein extract, an indirect slide-immunofluorescence assay and fluorescence-activated flow cytometry using the whole organism as antigen. The ELISA method using the protein antigen was the only technique that showed a significant difference between patients and controls; a lower antibody response was found in the seborrhoeic dermatitis patients compared to healthy controls.
- Subjects
MALASSEZIA ovale; SKIN inflammation; ENZYME-linked immunosorbent assay
- Publication
Clinical & Experimental Dermatology, 1991, Vol 16, Issue 5, p339
- ISSN
0307-6938
- Publication type
Article
- DOI
10.1111/j.1365-2230.1991.tb00396.x