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- Title
Synthesis and crystal structure of two derivatives of benzodiazepines.
- Authors
Swamy, G. Y. S. K.; Sridhar, B.; Ravikumar, K.; Reddy, K. S.; Reddy, V. V. N.
- Abstract
Two benzodiazepine derivatives, C23H22N2O (I), 2-methyl-8-methoxy-2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine, and C22H17N3O2Br2 (II), 2-methyl-7-nitro-2,4-bis(4′-bromophenyl)-2,3-dihydro-1H-1,5-benzodiazepine, were studied by single crystal X-ray diffraction method. Compound (I) crystallizes in the monoclinic system, space group P21/ c, a = 13.1703(17) Å, b = 11.1990(14) Å, c = 12.9093(16) Å, β = 107.831(2)°, V = 1812.6(3) Å3, Z = 4. Compound (II) crystallizes in the monoclinic system, space group P21/ n, a = 11.7345(12) Å, b = 12.7477(13) Å, c = 13.5965(14) Å, β = 95.221(2)°, V = 2025.4(4) Å3, Z = 4. The molecules of (I) and (II) have T-shape form with the diazepine ring at the junction point. The seven membered central benzodiazepine ring in both structures adopt a twist-boat conformation. The crystal packing is stabilized by C-H...π (in I) and C-H...O (in II) interactions.
- Subjects
BENZODIAZEPINES; OPTICAL diffraction; CRYSTALLIZATION; CHEMISTRY; DIAZEPINES; MOLECULES
- Publication
Journal of Structural Chemistry, 2008, Vol 49, Issue 4, p775
- ISSN
0022-4766
- Publication type
Article
- DOI
10.1007/s10947-008-0112-6