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- Title
Synthesis and Antifungal Activity of Cuminic Acid Derivatives.
- Authors
Yang, Jian; Gao, Yang; Liu, Hui; Tang, Xiaorong
- Abstract
A series of benzamide derivatives (compounds 1-29) was synthesized based on the lead compound cuminic acid. The crystal structure of compound 11 was characterized by single crystal X-ray diffraction. The antifungal activity of the synthesized compounds was determined against seven plant pathogenic fungi, namely Rhizoctonia solani, Gibberella zeae, Helminthosporium maydis, Sclerotinia sclerotiorum, Botrytis cinerea, Coniothyrium diplodiella, and Coniothyrium lagenarium. Preliminary results indicated that most of them revealed significant antifungal activity. Among them, compound 22 showed the strongest activity and possessed better antifungal activity against H. maydis, S. sclerotiorum, and B. cinerea than carbendazim.
- Subjects
ORGANIC acids; CHEMICAL synthesis; ANTIFUNGAL agents; BENZAMIDE; CRYSTAL structure; X-ray diffraction
- Publication
Chemistry of Natural Compounds, 2017, Vol 53, Issue 6, p1112
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-017-2212-z