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- Title
Particulate threats: aryl hydrocarbon receptor, alveolar epithelium, environmentally persistent free radicals, and endothelial dysfunction.
- Authors
Gowdy, Kymberly M; Shannahan, Jonathan
- Abstract
This article discusses the health effects of particulate matter, a type of air pollutant generated by various sources such as vehicle exhaust and power plants. The particulate matter contains environmentally persistent free radicals, which can cause oxidative stress in the lungs and throughout the body. The mechanism by which particulate matter and free radicals lead to cardiovascular dysfunction is not fully understood. The article focuses on the role of the aryl hydrocarbon receptor (AhR) and its activation by free radicals in pulmonary epithelial cells. The study found that mice lacking AhR expression in alveolar type-II cells were protected against free radical-induced vascular dysfunction. These findings have implications for understanding the mechanisms of environmental exposure and could potentially lead to therapeutic treatments for cardiopulmonary diseases.
- Subjects
ARYL hydrocarbon receptors; FREE radicals; LUNGS; ENDOTHELIUM diseases; EPITHELIUM
- Publication
Toxicological Sciences, 2024, Vol 199, Issue 2, p161
- ISSN
1096-6080
- Publication type
Article
- DOI
10.1093/toxsci/kfae036