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- Title
Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial* Presented in part as an oral presentation at the 19th annual meeting of the ESHRE in Madrid, July 1, 2003.
- Authors
E.R. Klinkert; F.J.M. Broekmans; C.W.N. Looman; J.D.F. Habbema; E.R. te Velde
- Abstract
BACKGROUND: The aim of this study was to evaluate the effect of doubling the starting dose of gonadotrophins on the ovarian response in IVF patients with a low antral follicle count (AFC). METHODS: Fifty-two patients with an AFC of <5 follicles of 25?mm diameter before starting their first IVF cycle participated in this randomized controlled trial. They were randomized by opening a sealed envelope, receiving either 150?IU (group I, n=26) or 300?IU (group II, n=26) of rFSH as a starting dose. The main outcome measures of the study were number of oocytes, poor response (<4 oocytes at retrieval or cancellation due to insufficient follicle growth) and ongoing pregnancy (12 weeks of gestation). RESULTS: The groups were comparable regarding patient characteristics and outcome of the IVF treatment. The median number of oocytes collected was 3 for both groups (P=0.79). The difference in the mean number of oocytes was 0.3 oocytes in favour of group I (P=0.69). Sixty-five per cent of the patients in group I experienced a poor response and 62% in group II. The ongoing pregnancy rate was 8% in group I and 4% in group II (P=0.55). CONCLUSIONS: Expected poor response patients, defined as patients with an AFC <5, are likely not to benefit from a higher starting dose of gonadotrophins in IVF.
- Subjects
PREGNANCY; CONCEPTION; PHYSIOLOGY; REPRODUCTION
- Publication
Human Reproduction, 2005, Vol 20, Issue 3, p611
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deh663