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- Title
An eco-friendly catalytic route for one-pot synthesis of 2-amino-6-(2-oxo-2 Hchromen-3-yl)-4-arylnicotinonitrile derivatives by silica-supported perchloric acid (HClO-SiO) under solvent-free conditions.
- Authors
Ghashang, Majid; Aswin, Krishnamoorthy; Mansoor, Syed
- Abstract
A facile and environmentally benign synthesis of some 2-amino-6-(2-oxo-2 H-chromen-3-yl)-4-arylnicotinonitrile derivatives from the reaction of 3-acetylcoumarin, aromatic aldehydes, and malononitrile under solvent-free condition in the presence of silica-supported perchloric acid (HClO-SiO) is described. The ability to reuse the catalyst, the high yields, and ease of purification are the important features of this process.
- Subjects
AMINO compound synthesis; NITRILE derivatives; SILICA; PERCHLORIC acid; SOLVENTS; COUMARINS; AROMATIC aldehydes
- Publication
Research on Chemical Intermediates, 2014, Vol 40, Issue 3, p1135
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-013-1027-1