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- Title
The neuronal background K<sub>2P</sub> channels: focus on TREK1.
- Authors
Honoré, Eric
- Abstract
Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane segments and two pore-forming domains that are arranged in tandem and function as either homo- or heterodimeric channels. This structural motif is associated with unusual gating properties, including background channel activity and sensitivity to membrane stretch. Moreover, K2P channels are modulated by a variety of cellular lipids and pharmacological agents, including polyunsaturated fatty acids and volatile general anaesthetics. Recent in vivo studies have demonstrated that TREK1, the most thoroughly studied K2P channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression.
- Subjects
NEURONS; POTASSIUM channels; DIMERS; MEMBRANE proteins; UNSATURATED fatty acids; ANESTHETICS; ACTIVE biological transport
- Publication
Nature Reviews Neuroscience, 2007, Vol 8, Issue 4, p251
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn2117