Discusses research being done on a transgenic mouse that developed amyloid-Β plaques and tangles of hyperphosphorylated tau protein in Alzheimer's disease (AD)-relevant brain regions. Reference to study by Frank LaFerla and colleagues published in the July 31, 2003 issue of the journal "Neuron." Influence of amyloid-Β on the formation of tau proteins; Physiological manifestations of AD.