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- Title
Interferon-Gamma Inducible Protein-10: Not a Mortality Marker for COVID-19 Disease.
- Authors
ISLAM, Mahmud; DHEIR, Hamad; SAHIN, Elif OZOZEN; YAYLACI, Selcuk; AYDIN, Abdulkadir; PINAR, Musa; GUCLU, Ertugrul; GENC, Ahmed Cihad; KOROGLU, Mehmet; KARABAY, Oguz
- Abstract
Objective: Interferon-gamma inducible protein-10 (IP-10) released from macrophages is associated with thrombosis. We aimed to investigate patients' biochemical markers following severe COVID-19, concentrating on the role of IP-10 in mortality. Materials and Methods: In our study, we retrospectively evaluated data from 88 (females, 44.3%) severe patients followed in our university hospital's intensive care unit (ICU). We obtained demographic and laboratory data from our study population's files and electronic records, including D-dimer, ferritin, uric acid, IP-10 values, and other biochemical markers. Results: The mean age of all 88 patients with COVID-19 infection followed in the ICU was 70.5 ±10 years. The median for lymphocyte count was 1.3 (1-2.1) vs 0.8 (0.5-1.1) K/uL, ferritin 151 (90.7-255) vs 624 (296-1254) mcg/L, D-dimer 386 (293.5-650) vs 1280 (871-2245) ug/L, LDH 220 (185-286) vs 429.5 (368-560) U/L with a pvalue of <0.05 in survivors vs non-survivors respectively. On the other hand, the level of IP-10 was 21.3 (13.2-31.6) vs 26.6 (11.4-43.6) pg/mL with a p-value of 0.04. Conclusion: In this study, in which non-survivors and survivors were compared in severe COVID-19 patients, it was found that ferritin and D-dimer were good predictors of mortality, while IP-10 could not be a predictor of mortality.
- Subjects
INTERFERON gamma; COVID-19 pandemic; INTENSIVE care units; THROMBOSIS; FIBRIN fragment D; BIOMARKERS
- Publication
Online Turkish Journal of Health Sciences (OTJHS) / Online Türk Sağlık Bilimleri Dergisi, 2023, Vol 8, Issue 3, p363
- ISSN
2459-1467
- Publication type
Article
- DOI
10.26453/otjhs.1276809