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- Title
Valsartan protects HK-2 cells from contrast media-induced apoptosis by inhibiting endoplasmic reticulum stress.
- Authors
Peng, Ping‐an; Wang, Le; Ma, Qian; Xin, Yi; Zhang, Ou; Han, Hong‐ya; Liu, Xiao‐li; Ji, Qing‐wei; Zhou, Yu‐jie; Zhao, Ying‐xin
- Abstract
Contrast-induced acute kidney injury (CI-AKI) is associated with increasing in-hospital and long-term adverse clinical outcomes in high-risk patients undergoing percutaneous coronary intervention (PCI). Contrast media (CM)-induced renal tubular cell apoptosis is reported to participate in this process by activating endoplasmic reticulum (ER) stress. An angiotensin II type 1 receptor (AT1R) antagonist can alleviate ER stress-induced renal apoptosis in streptozotocin (STZ)-induced diabetic mice and can reduce CM-induced renal apoptosis by reducing oxidative stress and reversing the enhancement of bax mRNA and the reduction of bcl-2mRNA, but the effect of the AT1R blocker on ER stress in the pathogenesis of CI-AKI is still unknown. In this study, we explored the effect of valsartan on meglumine diatrizoate-induced human renal tubular cell apoptosis by measuring changes in ER stress-related biomarkers. The results showed that meglumine diatrizoate caused significant cell apoptosis by upregulating the expression of ER stressmarkers, including glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF4), CCAAT/enhancer-binding protein-homologous protein (CHOP) and caspase 12, in a time- and dose-dependent manner, which could be alleviated by preincubation with valsartan. In conclusion, valsartan had a potential nephroprotective effect on meglumine diatrizoate-induced renal cell apoptosis by inhibiting ER stress.
- Subjects
VALSARTAN; CONTRAST media; APOPTOSIS; ENDOPLASMIC reticulum; KIDNEY injuries; LABORATORY mice; THERAPEUTICS
- Publication
Cell Biology International, 2015, Vol 39, Issue 12, p1408
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1002/cbin.10521