We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gender‐Specific Association Between <italic>ABCC2</italic> ‐24C>T SNP and Reduction in Triglycerides in Chilean Patients Treated With Atorvastatin.
- Authors
Prado, Yalena; Arencibia, Alberto; Zambrano, Tomás; Salazar, Luis A.
- Abstract
Abstract: Statins are the first‐line therapy prescribed to lower plasma cholesterol levels. Although being safe and showing several beneficial cholesterol‐independent pleiotropic effects, a significant variability regarding statin's therapeutic goals has been abundantly documented, but less understood. We aimed to investigate the influence of the <italic>ABCC2</italic> ‐24C>T single nucleotide polymorphism on Chilean hypercholesterolaemic individuals treated for 4 weeks with 10 mg/day atorvastatin. A total of 127 individuals medicated with atorvastatin 10 mg/day/4 weeks were included. Lipid profiles were determined before and after drug administration by conventional assays. Genotyping of the <italic>ABCC2</italic> rs717620 SNP (‐24C>T) was performed with TaqMan® Drug Metabolism Genotyping Assays. As expected, atorvastatin reduced TC, LDL‐C and TG concentrations (<italic>p</italic> < 0.05). Also, HDL‐C levels were increased (<italic>p</italic> < 0.05). Minor allele frequency for the rs717620 was 0.232. Overall, atorvastatin response was not associated with the <italic>ABCC2</italic> rs717620 SNP (<italic>p</italic> > 0.05). Nonetheless, in male individuals carrying the ‐24T allele, we observed an attenuated reduction in both TG values and the TG/HDL‐C ratio after 10 mg/day atorvastatin. This study indicates that TG levels and the TG/HDL‐C ratio are affected by the rs717620 SNP in Chilean males but not female individuals after atorvastatin treatment.
- Subjects
TRIGLYCERIDES; ATORVASTATIN; SINGLE nucleotide polymorphisms; LOW density lipoproteins; HYPERCHOLESTEREMIA
- Publication
Basic & Clinical Pharmacology & Toxicology, 2018, Vol 122, Issue 5, p517
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/bcpt.12943