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- Title
Currentin vivoAssays for Cutaneous Toxicity: Local and Systemic Toxicity Testing.
- Authors
Auletta, Carol S.
- Abstract
This review provides an update on current (June 2004)in vivoassays for evaluations of local and systemic cutaneous toxicity. As the science of toxicology and safety assessment grows and evolves, an increasing number ofin vitroassays and screening procedures designed to minimize the use of animals in cutaneous toxicity evaluations have been validated or are currently in development. However, in some cases, it remains necessary to evaluate the effects of new drugs or chemicals in an animal model in order to protect human health. Current regulatory requirements and study designs for local and systemicin vivocutaneous toxicity evaluations, as well as discussions of procedures unique to cutaneous toxicity evaluation are presented in this review.
- Subjects
TOXICITY testing; TOXICOLOGY; HEALTH risk assessment; DIAGNOSTIC services; POISONS; PHARMACOLOGY
- Publication
Basic & Clinical Pharmacology & Toxicology, 2004, Vol 95, Issue 5, p201
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2004.pto950501.x