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- Title
Comment on "Serially Combining Epidemiological Designs Does Not Improve Overall Signal Detection in Vaccine Safety Surveillance".
- Authors
Huang, Wan-Ting; Chen, Robert T.; Cassard, Caroline
- Abstract
The comment discusses a study that examined the effectiveness of different methods for detecting signals of adverse events related to vaccines. The study compared three approaches: the historical comparator method, the self-controlled case series (SCCS) method, and a combination of the two. The authors concluded that combining these methods did not improve overall signal detection in vaccine safety surveillance. However, they also acknowledged that a serial approach could still be beneficial in reducing systematic errors if used in a different way. They suggested actions to refine signals and make hypothesis testing timelier, such as checking data quality and replicating studies using different source data. The comment was written by Wan-Ting Huang, Robert T. Chen, and Caroline Cassard.
- Subjects
SIGNAL detection; VACCINE safety; PANDEMIC preparedness; VACCINATION complications; FALSE positive error
- Publication
Drug Safety, 2024, Vol 47, Issue 4, p401
- ISSN
0114-5916
- Publication type
Letter to the Editor
- DOI
10.1007/s40264-024-01410-y