We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
CURCUMIN MODERATES LUNG DAMAGE INDUCED BY MECHLORETHAMINE.
- Authors
Zeki Ilker, MAJ KUNAK; Enis, MAJ MACIT; Mehmet, MAJ TOYGAR; Bulent, MAJ KURT; Turgut, MAJ TOPAL; Ahmet, COL KORKMAZ
- Abstract
OBJECTIVES: Chemical warfare agents are important among mass destruction weapons. Under this main group, mustard gas is still known as “king of warfare agents” since there is no antidote. It is cheap and easy to manufacture, have long period of storage, so, is still a popular agent. After prohibition of Sulfur mustard on World War II, analogs like HN1,2 and 3 were devoloped. MATERIAL AND METHODS: The study was performed to test curcumin for its capability in protecting the lungs of injured male Wistar rats with nitrogen mustard. Lung mustard toxicity was induced via an intratracheally injection of HN2 (0.5 mg/kg) dissolved in saline (100 ...). Control animals were injected the same amount of saline only. Curcumin was administered per-orally daily with a dose of 50 mg/kg beginning 1 h before HN2 application and continued every 12 h for six replications. RESULTS: MDA results indicate that there was a strong oxidative stress in HN2 group also HN2 administration did not affect the control Cu/Zn-SOD levels. But in SOD, HN2 depressed the GPx levels. Curcumin 50 mg/kg elevated both antioxidant enzymes and signifi cantly lowered MDA to nearly physiological levels and effectively combated the oxidative effects of HN2. CONCLUSION: Sustained elevated antioxidant enzymes after cessation of curcumin support further investigation into this topic. The results also indicate that tissue damage was not totally prevented by curcumin and repair processes were underway. But it is still a promising molecule for the treatment of mustard gas which has not got a spesifi c antidote yet.
- Publication
Balkan Military Medical Review, 2014, Vol 17, p16
- ISSN
1107-6275
- Publication type
Article