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- Title
The Prognostic Role of Lactate Concentrations after Aneurysmal Subarachnoid Hemorrhage.
- Authors
Ndieugnou Djangang, Narcisse; Ramunno, Pamela; Izzi, Antonio; Garufi, Alessandra; Menozzi, Marco; Diaferia, Daniela; Peluso, Lorenzo; Prezioso, Chiara; Talamonti, Marta; Njimi, Hassane; Schuind, Sophie; Vincent, Jean-Louis; Creteur, Jacques; Taccone, Fabio Silvio; Gouvea Bogossian, Elisa
- Abstract
Blood lactate concentrations are often used to assess global tissue perfusion in critically ill patients; however, there are scarce data on lactate concentrations after subarachnoid hemorrhage (SAH). We aimed to assess the prognostic role of serial blood lactate measurements on hospital mortality and neurological outcomes at 3 months after SAH. We reviewed all SAH patients admitted to the intensive care unit from 2007 to 2019 and recorded the highest daily arterial lactate concentration for the first 6 days. Patients with no lactate concentration were excluded. Hyperlactatemia was defined as a blood lactate concentration >2.0 mmol/L. A total of 456 patients were included: 158 (35%) patients died in hospital and 209 (46%) had an unfavorable outcome (UO) at 3 months. The median highest lactate concentration was 2.7 (1.8–3.9) mmol/L. Non-survivors and patients with UO had significantly higher lactate concentrations compared to other patients. Hyperlactatemia increased the chance of dying (OR 4.19 (95% CI 2.38–7.39)) and of having UO in 3 months (OR 4.16 (95% CI 2.52–6.88)) after adjusting for confounding factors. Therefore, initial blood lactate concentrations have prognostic implications in patients with SAH; their role in conjunction with other prognostic indicators should be evaluated in prospective studies.
- Subjects
SUBARACHNOID hemorrhage; LACTATES; BLOOD lactate; INTENSIVE care patients; HOSPITAL mortality
- Publication
Brain Sciences (2076-3425), 2020, Vol 10, Issue 12, p1004
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci10121004