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- Title
Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer.
- Authors
Choi, Stephen Y. C.; Ribeiro, Caroline Fidalgo; Wang, Yuzhuo; Loda, Massimo; Plymate, Stephen R.; Uo, Takuma
- Abstract
There is an urgent need for exploring new actionable targets other than androgen receptor to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has reemerged as a hallmark of cancer that drives and supports oncogenesis. In this regard, it is important to understand the relationship between distinctive metabolic features, androgen receptor signaling, genetic drivers in prostate cancer, and the tumor microenvironment (symbiotic and competitive metabolic interactions) to identify metabolic vulnerabilities. We explore the links between metabolism and gene regulation, and thus the unique metabolic signatures that define the malignant phenotypes at given stages of prostate tumor progression. We also provide an overview of current metabolism-based pharmacological strategies to be developed or repurposed for metabolism-based therapeutics for castration-resistant prostate cancer.
- Subjects
CASTRATION-resistant prostate cancer; ANDROGEN receptors; METABOLIC regulation; PROSTATE cancer; PROSTATE tumors
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 11, p1590
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12111590