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- Title
THE DISTRIBUTION OF HLA ANTIGENS IN BONE MARROW AND KIDNEY RECIPIENTS: A SINGLE CENTER EXPERIENCE.
- Authors
MUŞABAK, Uğur; ENIEKIN, Ümit; GENÇEL, Mustafa; ÇINAR, Oktay; ÇIÇEK, Kazım; GÜVERCIN, Yasin Semih; SEÇKIN, Yılmaz; YAMAN, Ahmet Ensar; BAHAR, Mecit; INAN, Serdar; YAŞAR, Sinan; YANMIŞ, Naile; GÜVEN, Gülbetül; TARGUT, Servet; SEVINÇ, Uğur; ÖZDAMAR, Fatih; GÖKÇEK, Zeynep Eslem; AKYILDIRIM, Süreyya; MUTLU, Derviş Melih; ÖZTÜRK, Asel
- Abstract
OBJECTIVE: It is well known that Human Leukocyte Antigen (HLA) allele frequencies show some associations in leukemias and chronic renal failure. The aim of this study was to investigate the frequencies of HLA antigens in bone marrow or kidney ransplant recipients and their donors in our center and reveal the variations of these cohorts. DESIGN AND METHODS: We performed a retrospective analysis based on 1662 HLA typing results registered in our center between the years of 2005-2014. The study group was composed of transplant recipients (192 renal, 352 bone marrow) and donors (292 renal, 826 bone marrow). HLA-A, -B, -DQ and -DR typings were done by using microlymphocytotoxicity (NIH protocol) and polymerase chain reaction with sequence specifi c primer or sequence specifi c oligonucleotide (PCR-SSP, -SSO) methods. SPSS (SPSS 11.5, SPSS Inc., Chicago, IL, USA) statistical package was used for statistical analyses. The frequencies of HLA antigens in the cohorts were assessed and compared with each other by using Chi-Square test or Fisher‘s Exact test, which was appropriated. A P value of <0.05 was considered as indicating a signifi cant difference. RESULTS: the most common HLA antigens were HLA-A2 (11.9 %), HLA-A24 (9.4 %), HLA-B35 (9.6 %), HLA-B51 (8.3 %), HLA-Cw4 (8.8 %), HLA-Cw7 (8.6 %), HLA-DQ3 (13 %), HLA-DQ5 (6.4 %) and HLA-DR11 (6.2 %), HLA-DR4 (5.7 %) in bone marrow recipients, and HLA-A2 (19.5 %), HLA-A24 (15.4 %), HLA-B35 (17.7 %), HLA-B51 (11.9 %), HLA-Cw4 (14.9 %), HLA-Cw7 (12 %), HLA-DQ3 (16.4 %), HLA-DQ5 (6.9 %) and HLA-DR11 (7.1 %), HLA-DR4 (5.2 %) in kidney recipients. HLA-A and HLA-B loci variations in bone marrow and kidney recipients were found to be signifi cantly different from each other (p= 0.31 and 0.34, respectively). CONCLUSION: the variations in distribution of HLA-A and HLA-B antigens may play roles in the pathogenesis of leukemias and chronic renal failure.
- Publication
Balkan Military Medical Review, 2014, Vol 17, p36
- ISSN
1107-6275
- Publication type
Article