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- Title
A 20-year follow-up study of identical twin sisters with immunoglobulin A nephropathy.
- Authors
Okabe, Masahiro; Tsuboi, Nobuo; Ueda, Hiroyuki; Hishida, Erika; Miyazaki, Yoichi; Yokoo, Takashi
- Abstract
Immunoglobulin A nephropathy (IgAN) is characterized by diverse clinicopathological phenotypes. Herein we present a follow-up study of previously reported identical twin sisters with IgAN. The older sister exhibited more severe kidney histopathology and proteinuria and a lower birthweight than did her younger sister, and only the older sister experienced two childbirths. These raised concerns regarding her kidney outcomes. However, with timely multidisciplinary treatments, the older sister's kidney function remained preserved after 20 years of IgAN history. Our findings indicate the significant contribution of environmental/epigenetic factors to IgAN progression and the need for tailored medical care corresponding to life events.
- Subjects
TWINS; MONOZYGOTIC twins; IGA glomerulonephritis; TWIN studies; KIDNEY physiology
- Publication
Clinical Kidney Journal, 2024, Vol 17, Issue 4, p1
- ISSN
2048-8505
- Publication type
Article
- DOI
10.1093/ckj/sfae073