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- Title
Is an 8‐week regimen of glecaprevir/pibrentasvir sufficient for all hepatitis C virus infected patients in the real‐world experience?
- Authors
Zarębska‐Michaluk, Dorota; Jaroszewicz, Jerzy; Pabjan, Paweł; Łapiński, Tadeusz W; Mazur, Włodzimierz; Krygier, Rafał; Dybowska, Dorota; Halota, Waldemar; Pawłowska, Małgorzata; Janczewska, Ewa; Buczyńska, Iwona; Simon, Krzysztof; Dobracka, Beata; Citko, Jolanta; Laurans, Łukasz; Tudrujek‐Zdunek, Magdalena; Tomasiewicz, Krzysztof; Piekarska, Anna; Sitko, Marek; Białkowska‐Warzecha, Jolanta
- Abstract
Background and Aims: The revolution of the antiviral treatment of hepatitis C virus (HCV) infection resulting in higher effectiveness came with the introduction of direct‐acting antivirals with pangenotypic regimens as a final touch. Among them, the combination of glecaprevir (GLE) and pibrentasvir (PIB) provides the opportunity for shortening therapy to 8 weeks in the majority of patients. Because of still insufficient evaluation of this regimen in the real‐world experience, our study aimed to assess the efficacy and safety of 8‐week GLE/PIB in chronic hepatitis C patients depending on liver fibrosis and genotype (GT). Methods: The analysis included patients who received GLE/PIB for 8 weeks selected from the EpiTer‐2 database, large retrospective national real‐world study evaluating antiviral treatment in 12 584 individuals in 22 Polish hepatology centers. Results: A total of 1034 patients with female predominance (52%) were enrolled in the analysis. The majority of them were treatment naïve (94%), presented liver fibrosis (F) of F0–F3 (92%), with the most common GT1b, followed by GT3. The overall sustained virologic response after exclusion of nonvirologic failures was achieved in 95.8% and 98%, respectively (P = 0.19). In multivariate logistic regression HCV GT‐3 (beta = 0.07, P = 0.02) and HIV infection (beta = −0.14, P < 0.001) were independent predictors of nonresponse. Conclusions: We demonstrated high effectiveness of 8‐week GLE/PIB treatment in a non‐GT3 population irrespective of liver fibrosis stage. Comparable efficacy was achieved in non‐cirrhotic patients regardless of the genotype, including GT3 HCV.
- Subjects
HEPATITIS C virus; PATIENTS' attitudes; CHRONIC hepatitis C; HIV infections; ANTIVIRAL agents
- Publication
Journal of Gastroenterology & Hepatology, 2021, Vol 36, Issue 7, p1944
- ISSN
0815-9319
- Publication type
Article
- DOI
10.1111/jgh.15337