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- Title
Shaping development with ESCRTs.
- Authors
Rusten, Tor Erik; Vaccari, Thomas; Stenmark, Harald
- Abstract
Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.
- Subjects
ORIGIN of life; CYTOKINESIS; MESSENGER RNA; CELLULAR signal transduction; YEAST genetic engineering; BIOCHEMISTRY; POLARITY (Chemistry)
- Publication
Nature Cell Biology, 2012, Vol 14, Issue 1, p38
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2381