We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma.
- Authors
Rabold, Katrin; Zoodsma, Martijn; Grondman, Inge; Kuijpers, Yunus; Bremmers, Manita; Jaeger, Martin; Zhang, Bowen; Hobo, Willemijn; Bonenkamp, Han J.; de Wilt, Johannes H. W.; Janssen, Marcel J. R.; Cornelissen, Lenneke A. M.; van Engen-van Grunsven, Ilse C. H.; Mulder, Willem J. M.; Smit, Jan W. A.; Adema, Gosse J.; Netea, Mihai G.; Li, Yang; Xu, Cheng-Jian; Netea-Maier, Romana T.
- Abstract
Myeloid cells, crucial players in antitumoral defense, are affected by tumor-derived factors and treatment. The role of myeloid cells and their progenitors prior to tumor infiltration is poorly understood. Here we show single-cell transcriptomics and functional analyses of the myeloid cell lineage in patients with non-medullary thyroid carcinoma (TC) and multinodular goiter, before and after treatment with radioactive iodine compared to healthy controls. Integrative data analysis indicates that monocytes of TC patients have transcriptional upregulation of antigen presentation, reduced cytokine production capacity, and overproduction of reactive oxygen species. Interestingly, these cancer-related pathological changes are partially removed upon treatment. In bone marrow, TC patients tend to shift from myelopoiesis towards lymphopoiesis, reflected in transcriptional differences. Taken together, distinct transcriptional and functional changes in myeloid cells arise before their infiltration of the tumor and are already initiated in bone marrow, which suggests an active role in forming the tumor immune microenvironment. Myeloid cells contribute to the tumor microenvironment of thyroid cancers, but their functional relevance is lesser known. Here authors show that myeloid cells infiltrating non-medullary thyroid carcinomas upregulate their antigen presentation-related genes, release less cytokines and over-produce reactive oxygen species, with transcriptional changes already present in extra-tumoral myeloid cells.
- Subjects
MYELOID cells; THYROID cancer; PLASMACYTOMA; PROGENITOR cells; IODINE isotopes; REACTIVE oxygen species
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-33907-4