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- Title
Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.
- Authors
Strauss, Sarah; Korympidou, Maria M.; Ran, Yanli; Franke, Katrin; Schubert, Timm; Baden, Tom; Berens, Philipp; Euler, Thomas; Vlasits, Anna L.
- Abstract
Motion sensing is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found that some bipolar cells are radially direction selective, preferring the origin of small object motion trajectories. Using a glutamate sensor, we directly observed bipolar cells synaptic output and found that there are radial direction selective and non-selective bipolar cell types, the majority being selective, and that radial direction selectivity relies on properties of the center-surround receptive field. We used these bipolar cell receptive fields along with connectomics to design biophysical models of downstream cells. The models and additional experiments demonstrated that bipolar cells pass radial direction selective excitation to starburst amacrine cells, which contributes to their directional tuning. As bipolar cells provide excitation to most amacrine and ganglion cells, their radial direction selectivity may contribute to motion processing throughout the visual system. Motion vision is critical for survival. Here the authors show that motion detection occurs already in bipolar cells of the mouse retina, which may contribute to motion processing throughout the visual system.
- Subjects
BIPOLAR cells; RETINA; MICE; GLUTAMATE receptors; FLUORESCENCE angiography
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-32762-7