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- Title
Spectroscopic Investigation of Organotin(IV) Derivatives of 7-Epiclusianone: a preliminary in vitro Antitumor Evaluation of the HN-5 Human Carcinoma Cell.
- Authors
Vieira, Flaviana T.; da S. Maia, Jos' Roberto; Vilela, Marcelo J.; Ardisson, Jos D.; dos Santos, Marcelo; de Oliveira, Tânia T.; Nagern, Tanus J.
- Abstract
A series of organotin(IV) compounds have been prepared by reaction with 7-epiclusianone (Epi), a natural product extracted from fruits of Rheedia gardneriana. This compound has an interesting motif with several coordinating sites for metal-ligand bond formation, and in solution, it shows a keto-enol tautomerism. The NMR of the organotin(IV) derivatives has revealed intramolecular hydrogen bonding, indicating that the keto-enol tautomerism of 7-epiclusianone is not involved upon coordination of those, but the absence of this bonding type in the case of the SnCl4 derivative suggests a strong interaction. The Mössbauer spectroscopy has revealed five- and six-fold coordination for the organotin(IV) and SnCl4 derivatives in the solid state. However, in solution all tin complexes have six-fold coordination, as shown by 119Sn NMR. The overall data point out that the organotin(IV) precursors SnClxPh4-x (x = 1, 2) are weakly bonded to the 7-epiclusianone, except the SnCl4. Bioassay in vitro of the substance test [SnClPh3(Epi)] (1) has been investigated using two epithelial cells: normal MDCK from canine kidney, and IIN-5 from a human carcinoma of the tongue. The results clearly demonstrate that the time for cellular reproduction has been reduced in the presence of the substance test.
- Publication
Main Group Metal Chemistry, 2009, Vol 32, Issue 5, p235
- ISSN
0792-1241
- Publication type
Article