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- Title
Plasma-Activated Polypropylene Mesh-Gelatin Scaffold Composite as Potential Implant for Bioactive Hernia Treatment.
- Authors
Gorgieva, Selestina; Modic, Martina; Dovgan, Barbara; Kaisersberger‐Vincek, Maja; Kokol, Vanja
- Abstract
Novel, polypropylene mesh (PPmesh) - gelatin scaffold (GELscaffold) composites are prepared from O2-plasma activated PPmesh, coated with GEL solution being in-situ structured in a 3D scaffold with by-preparation tuned, gradual porosity. The fabricated biomimetic-like composites demonstrate frequency-dependent rheological behaviour and high (up to 100%) intrinsic and/or by ϵ-poly- L-lysine evoked antibacterial activity against S. aureus and E. coli, latter demonstrating preparation-dependant releasing profile, without triggering in-vitro cytotoxicity. Finally, long-term (up to 2 months) biodegradation resistance highlight the composite potential as active, biomimetic barrier in hernia treatment.
- Subjects
POLYPROPYLENE; COMPOSITE materials research; PLASMA gas research; POROSITY; RHEOLOGY
- Publication
Plasma Processes & Polymers, 2015, Vol 12, Issue 3, p237
- ISSN
1612-8850
- Publication type
Article
- DOI
10.1002/ppap.201400125