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- Title
Yoğun Bakım Ünitelerinde Yatan Hastalara ait Çeşitli Klinik Örneklerden İzole Edilen Candida Suşlarında Tür Dağılımının ve Antifungal Duyarlılıkların Araştırılması.
- Authors
Pelit, Süleyman; Uzun, Meltem
- Abstract
Objective: Infections caused by Candida species are becoming important causes of morbidity and mortality in intensive care patients. The aim of this study was to determine species distribution and antifungal susceptibility of 121 Candida species isolated from various clinical samples of intensive care unit patients in our center. Material and Methods: Species distribution and antifungal susceptibility of the isolates were determinated with VITEK 2 Compact System (BioMérieux, France). Results: The 121 Candida strains were identified as follows: 60 C.albicans (49.6%), 21 C. tropicalis (17.3%), 17 C. parapsilosis (14%), 15 C. glabrata (12.4%), 3 C. keyfr (2.5%), 2 C. krusei (1.7%), 1 C. lusitaniae, 1 C. famata and 1 C. lipolytica. All of the Candida strains were found to be susceptible to flucytosine, fluconazole, voricon-azole and caspofungin except C.krusei strains which are intrinsically resistant to fluconazole. Intermediate susceptibility to amphotericin B was determinated in four (3.4%) Candida strains and four (3.4%) strains were found to be resistant to amphotericin B. Minimum inhibitory concentration (MIC) values of the isolates with intermediate susceptibility and resistanceto amphotericin B were2 µg/mL and 8 µg/ mL respectively. Conclusion: Identification and susceptibility tests for Candida species should be performed for the proper management and treatment of patients with Candida infections.
- Subjects
AMPHOTERICIN B; ANTIFUNGAL agents; CANDIDA; CANDIDIASIS; CRITICALLY ill; DRUG resistance; INTENSIVE care units; PATIENTS; THERAPEUTICS
- Publication
Turkish Journal of Medical & Surgical Intensive Care Medicine / Dahili ve Cerrahi Yoğun Bakım Dergisi, 2016, Vol 7, Issue 2, p49
- ISSN
1309-1689
- Publication type
Article
- DOI
10.5152/dcbybd.2016.1050