We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hydroxyethyl Cellulose Promotes the Mucin Retention of Herbal Extracts Active against Streptococcus mutans.
- Authors
Livne, Shiri; Simantov, Sapir; Rahmanov, Arkadi; Jeffet, Uziel; Sterer, Nir
- Abstract
Streptococcus mutans is considered a major cariogenic bacterium. Most anti-cariogenic dentifrices are limited by a short exposure time. The aim of the present study was to test the hypothesis that adding a mucoadhesive agent to the formulation may increase its bioavailability and efficacy. We tested the effect of adding hydroxyethyl cellulose (HEC) to an herbal extract solution containing lavender, echinacea, sage, and mastic gum, which have been previously shown to be effective against Streptococcus mutans. Mucin-coated wells were treated with four test solutions: saline, herbal extracts, herbal extracts with HEC, and chlorhexidine. The wells were incubated with Streptococcus mutans and studied for biofilm formation (Crystal violet assay), acid production (lactate assay), acid tolerance (ATPase assay), and exopolysaccharide (EPS) production using fluorescent microscopy. The results showed that the addition of HEC to the herbal extract solution caused a significant reduction in Streptococcus mutans biofilm formation, lactic acid production, and EPS quantity (p < 0.001). These results suggest that HEC may be a beneficial added excipient to herbal extracts in an anti-cariogenic formulation.
- Subjects
STREPTOCOCCUS mutans; LACTIC acid; CELLULOSE; MUCINS; SALINE solutions; GENTIAN violet; MICROBIAL exopolysaccharides
- Publication
Materials (1996-1944), 2022, Vol 15, Issue 13, p4652
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma15134652