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- Title
Development and Validation of Hub Genes for Adrenal Aldosterone-Producing Adenoma by Integrated Bioinformatics Analysis.
- Authors
Cai, Hai; Chen, Shao-Ming; Ke, Zhi-Bin; Chen, Hang; Zhu, Jun-Ming; Lin, Ting-Ting; Huang, Fei; Wei, Yong; Zheng, Qing-Shui; Xue, Xue-Yi; Sun, Xiong-Lin; Xu, Ning
- Abstract
GO term enrichment analysis revealed that, during the development of APA, cellular divalent inorganic cation homeostasis, calcium ion homeostasis, collagen-containing extracellular matrix, transport vesicle, metal ion transmembrane transporter activity and monovalent inorganic cation transmembrane transporter activity played essential roles. We compared the gene expression profiles of APA samples and normal adrenal gland samples to identify differentially expressed genes (DEGs). Validation of Hub Genes in Two Independent Cohort Moreover, we utilized two independent datasets (GSE10927 and GSE33371) to validate the differential expression of these intersection genes between APA tissues and normal adrenal tissues.
- Subjects
BIOINFORMATICS; OVARIAN cancer; BLADDER cancer; SOMATOMEDIN A; GENES; ADENOMA
- Publication
International Journal of General Medicine, 2021, Vol 14, p10003
- ISSN
1178-7074
- Publication type
Article
- DOI
10.2147/IJGM.S330956