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- Title
CD8+ T CELL CYTOKINE & CYTOTOXIC PROTEIN PRODUCTION AND PROLIFERATION IS DIFFERENTIALLY REGULATED BY NORMAL AND RSV-INFECTED HUMAN BRONCHIAL EPITHELIAL CELLS.
- Authors
Telcian, Aurica G.; Mureşan, Adriana; Laza-Stanca, Vasile; Johnston, Sebastian L.; Stanciu, Luminiţa A.
- Abstract
It has been shown that epithelial cells have the capacity to present antigens to T lymphocytes. CD8+ T cell recognition of viral antigens presented by epithelial cells may be important in the clearance of respiratory viral infections, such as respiratory syncytial virus (RSV). Our aim was to investigate the effect of RSV-infected bronchial epithelial cells (BECs) on CD8+ T cell functions. Methods. CD8+ T cells were cultured by themselves (in the presence of media or RSV) or co-cultured with un-infected or RSV-infected BECs and CD8+ T cells cytokine production and proliferation was determined. Results. We found that CD8+ T cells co-cultured with normal BECs produced less cytokines and proliferated less compared with CD8+ T cells cultured with media alone, but in the CD8+ T cells co-cultured with RSV-infected BECs, cytokine production and proliferation were at high levels again. Conclusion. Normal bronchial epithelial cells inhibit CD8+ T cell cytokine production and proliferation but after RSV infection this regulatory function is lost. These findings suggest an important role for respiratory epithelial cells in controlling T cell functions in healthy lungs. Studying the interactions between human bronchial epithelial cells and local lymphocytes will help understanding the pathogenesis of various airway diseases.
- Subjects
RESPIRATORY syncytial virus; T cells; CYTOKINES; EPITHELIAL cells; ANTINEOPLASTIC agents; ANTIGENS; RESPIRATORY diseases; VIRUS diseases; LYMPHOCYTES; EPITHELIUM; IMMUNOGLOBULINS
- Publication
Clujul Medical, 2010, Vol 83, Issue 1, p64
- ISSN
1222-2119
- Publication type
Article