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- Title
Biochemical evaluation of creatinine in patients with chronic renal failure.
- Authors
Chaitanyashree, P.; Priya, A. Jothi; Devi, R. Gayatri
- Abstract
Introduction: Chronic renal failure is a progressive reduction in renal function. The kidneys lose their normal function, especially the excretory and regulatory functions which can be due to infections, autoimmune diseases, hypertension, cancer, diabetes, and toxic chemicals. The aim of this study is to estimate the serum creatinine levels in patients with chronic renal failure. Materials and Methods: A total of 50 patients who were diagnosed in kidney care center for renal failure based on their clinical history, clinical examinations, and renal function tests were randomly evaluated. Biomarker levels of serum creatinine before and after the hemodialysis session were screened. The creatinine levels in the samples were assessed by Jaffe Kinetic assay (22, 2002). Results: Serum creatinine level was significantly higher than normal range (up to 1.4 mg/dl) in renal failure patients undergoing dialysis (P < 0.005). Discussion: Renal failure is a gradual, progressive, and irreversible loss of normal functioning of kidneys. Increased levels of creatinine excretion in blood by impaired kidneys made complication in patients with renal failure before hemodialysis. Conclusion: Increase in serum creatinine level leads to chronic renal disease which can further lead to various complications such as hypertension and cardiovascular diseases.
- Subjects
CREATININE; CHRONIC kidney failure; KIDNEY failure; POISONS; KIDNEY diseases; CARDIOVASCULAR diseases
- Publication
Drug Invention Today, 2019, Vol 12, Issue 9, p1913
- ISSN
0975-7619
- Publication type
Article