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- Title
Screening methods for antihyperlipidemic activity: A review.
- Authors
Jijith, U. S.; Jayakumari, S.
- Abstract
Hyperlipidemia is characterized by increased level of cholesterol in the form of low-density lipoprotein (LDL), chylomicrons, very LDL (VLDL), etc. Development of new antihyperlipidemic drugs is a challenging job of researchers because most of the screening procedures are tedious and time-consuming. The present techniques for screening methods for antihyperlipidemic activity could be classified under in vitro and in vivo methods. The in vivo methods include Triton-, PTU-, and high-fat dietinduced hyperlipidemic models. In contrast, the reported in vitro methods are limited and include assay using Caco-2 cell lines and inhibitory activity on 3-Hydroxy-3-methylglutaryl-coenzyme A reductase. There is a lack of simple but sufficiently reproducible and sensitive in vitro technique for screening of antihyperlipidemic activity.
- Subjects
DRUG activation; DRUG use testing; HYPERLIPIDEMIA treatment; LOW density lipoproteins; DRUG bioavailability
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p257
- ISSN
0975-7619
- Publication type
Article