We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EPICARDIAL ADIPOSE TISSUE AND LEFT VENTRICULAR FUNCTION IN PATIENTS WITH ACUTE CORONARY SYNDROME.
- Authors
Alexandra, Muscalu Ana-Maria; Oana-Adriana, Matei; Alina-Cristina, Muntean; Pîslariu, Gabriela; Olariu, Simina-Otilia; Theodora, Benedek; Nora, Raţ
- Abstract
Background: Epicardial adipose tissue(EAT) is a metabolically active tissue associated with an increased risk in patients with coronary artery disease.There is a variety of mechanisms that could account for this, such as changes in blood pressure,arrhythmias,diabetes and metabolic syndrome,all leading to an overall systemic inflammation. Objective: We intended to evaluate the importance of EAT as a marker of vulnerability,on the clinical evolution of patients with acute coronary syndromes. Material and methods: We included a number of 77 ACS patients(unstable angina and acute myocardial infarction) who underwent complete clinical examination and 2D transthoracic echocardiographic,with included measurement of the EAT thickness (parasternal long axis view, at the anterior wall of the right ventricle,during diastole) but also evaluation of the left ventricular diameters,volumes (diastolic, systolic),function(ejection fraction - EF). Patients were divided into 2 groups:Group 1 -with acute myocardial infarction - (n=57) and Group 2 - with unstable angina - =20). Results: Mean age of patients included in the study was 63.75 +/- 12.89, with male predominance.The average EAT thickness for the total number of patients was 8.833 +/- 1.559 mm.No significant differences were found between patients with UA and AMI regarding age (p=0.87), or cardiovascular risk factors, but there was a significantly higher value of cholesterol in patients with AMI (204.1 +/- 41.96 ,p= 0.0076) and also a significantly increased value of the end-systolic left ventricular diameter(33.69 +/- 4.821,p=0.0223).The thickness of the EAT was significantly correlated with the value of the BMI (p<0.0001) and also with age (p=0.002) in the overall study population. Conclusions: Epicardial adipose tissue is associated with increased levels of cholesterol and also with a higher end-systolic left ventricular diameter in patients with AMI,which translates into a negative outcome in patients with coronary artery disease. Furthermore,there is a significant correlation between the thickness of the EAT and the values of BMI and age.
- Subjects
ACUTE coronary syndrome; VENTRICULAR ejection fraction; ADIPOSE tissues; ADIPOSE tissue diseases; MYOCARDIAL infarction; CORONARY disease; THICKNESS measurement; CORONARY arteries
- Publication
Acta Medica Marisiensis, 2019, Vol 65, p17
- ISSN
2068-3324
- Publication type
Article