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- Title
Efectividad de probióticos sobre síntomas, histología y tolerancia alimentaria en colitis ulcerativa.
- Authors
Sánchez-Morales, Adhara; Fabiola Pérez-Ayala, Mayte; Cruz-Martínez, Margarita; Arenas-Osuna, Jesús; Ramírez-Mendoza, Pablo; Alberto Ceniceros, Rodrigo; Marina Mora-Cañas, Eva; Cruz-Domínguez, Pilar; Ángel Saavedra-Salinas, Miguel
- Abstract
Background: Probiotics have been used in the adjuvant treatment of Ulcerative Colitis (UC). Objective: To evaluate the role of a combination of probiotics on the clinical, histological changes and feeding tolerance in patients with UC. Methods: An open CU patients with mild to moderate activity and clinical trial was conducted. Patients were randomized to receive or a combination of 6 strains of probiotics for 3 months while continuing their drug treatment established. CU activity was assessed by Truelove and Witts scale and histological findings by Gupta index. Descriptive statistics, Chi square test and Student t test for comparison of the two groups was performed. Results: In each group 17 patients were included. An improvement was found in the disease activity (52.9% vs. 23.5%, p = 0.07) and in histologic index (82.3% vs. 41.1%, p = 0.03) in patients treated with probiotics compared to the control group. Improved food tolerance was also observed in patients treated with probiotics. Conclusion: The study shows a beneficial short-term effect on symptoms, histological findings and feeding tolerance with the administration of a combination of 6 strains of probiotics in patients with UC.
- Publication
Revista Medica del IMSS, 2019, Vol 57, Issue 1, p9
- ISSN
0443-5117
- Publication type
Article